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- SIS page: NMST511
- Schedule: officially on Tuesday 9:00 -
10:30 in classroom K4
- Language: materials in English, instructed in Czech
(unless anybody requires English)
- Instructor e-mail: vavraj@karlin.mff.cuni.cz
- Lecture web page (from previous years): http://www.karlin.mff.cuni.cz/~kulich/vyuka/cens/index.html
- Note: Many exercises will be replaced by lectures
until sufficient theoretical background is covered.
- Hence, exercises will be scattered irregularly within the term
(mostly at its end).
- Course credit will be given for completing given homework
assignments in pre-specified deadlines (usually a morning before the
next exercise).
- Exercise class will be opened with discussion over previous
homework.
- We will go through the materials for exercise class together.
- There will be time for you to ask questions, work on given
assignments, …
- No attendance requirement for course credit.
Credit
- Satisfactory solution to given assignments by the prescribed
deadline.
If your solution will not be satisfactory enough, you
might be asked for revision.
Two revisions or late deliveries are
tolerated. Early communication increases my tolerance for late
deliveries.
Send your solution via email to address vavraj@karlin.mff.cuni.cz.
Recommended
form: Rmarkdown output
(PDF or HTML)
Overview
- Topic: Testing equality of
censored distributions
- Datasets: km_all.RData,
data(veteran)
- Assignment: Calculate and plot [KM], [NA] estimates
and smoothed estimator of hazard function when differentiating different
groups. Perform two-sample tests and decide (based on the plots) which
test statistic would be the most appropriate. Perform several real data
analyses and simulation study.
- Deadline: Thursday 8
December 9:00
- Topic: Building
Cox models for censored data (constant covariates)
- Dataset:
pbc dataset from
library(survival)
- Assignment: Perform exploratory analysis focused on
the influence of covariates on the survival probability. Build a
reasonable Cox model (starting from simple univariate models). Compare
your final Cox model to your final model from Exercise
1.
- Deadline: no report required
- Topic: Time-varying covariates
in the Cox model
- Dataset:
jasa and heart
dataset from library(survival)
- Assignment: Try to reproduce
heart
dataset from jasa. Build and interpret Cox model with
covariate indicating the time of heart transplantation and other fixed
covariates. Does transplantation help patients to survive longer? Plot
estimated survival functions.
- Deadline: no report required
Homework (11+18
December)
- Topic: Cox model - homework
assignment
- Dataset:
aids dataset from
library(JM)
- Assignment: Perform exploratory analysis focused on
the influence of covariates on the survival probability. Take into
account the longitudinal aspect of the data. Build a reasonable Cox
model (starting from simple univariate models).
- Deadline: end of exam period, Friday
11 January
- Topic: Generalizations of the Cox
model
- Dataset:
pbc and cgd
datasets from library(survival)
- Assignment: None, just admire what else could be
done with the Cox model.