Notifications

Some additional topics will be covered in lectures published around May 26 (or a bit later). They are not required at the exam.

Exam opportunities can be arranged in May, June, July or September upon request.

Schedule 

Lectures
Tuesday 14:00 - 15:30 K4  
Exercise Class
Tuesday 12:20 - 13:50 Praktikum KPMS

Course Notes & Contents 

The course notes are under development. So far they only include a part of the material covered in this course.

Distant learning

  1. Lecture March 17: Please study Sec. 3.2.2 (Woolf estimator), Sec. 3.2.3 (Mantel-Haenszel estimator), and 3.3 (Logistic regression for stratified case-control studies) in the course notes, pp. 30-35. Look at the supplementary reading in Breslow and Day I (Chap. IV, pp. 136–146, Chap. VI, pp. 192–242).
  2. Lecture March 24: Please study Sec. 4.1 (Principles of matching) and Sec. 4.2 (Classical methods for matched case-control studies) in the course notes, pp. 36-40. Look at the supplementary reading in Breslow and Day I (Chap. V, pp. 162-169).
  3. Lecture March 31: Please study Sec. 4.3 (Conditional logistic regression for matched case-control studies) in the course notes, pp. 41-43. Look at the supplementary reading in Breslow and Day I (Chap. VII, pp. 248-268).
  4. Lecture April 7: Please study Sec. 5.1 (Cohort study design) and Sec. 5.2 (Models for ungrouped cohort data) in the course notes, pp. 45-48. Look at the supplementary reading in Breslow and Day II (Chap. 5, pp. 178-197).
  5. Lecture April 14: Please study Sec. 5.3 ( Models for grouped cohort data) in the course notes, pp. 48-52. Look at the supplementary reading in Breslow and Day II (Chap. 3, pp. 82–91, Chap. 4, pp. 120–171).
  6. Lecture April 21: Please study Sec. 5.4 (Discrete Cox model) in the course notes, pp. 52-55.
  7. Lecture April 28: Please study Chapter 6 (Diagnostic tests) in the course notes, pp. 57-63.
  8. Lecture May 5: Audio recording of lecture can be downloaded from this link. Presentation slides are here.
  9. Lecture May 12: Audio recording of lecture can be downloaded from this link. Presentation slides are here. Look at example contents of a clinical trial protocol and an example of a full protocol (published in NEJM, 2017).
  10. Lecture May 19: Audio recording: Part A, Part B.
    Presentation slides are here. Look at an example of a Statistical Analysis Plan in a Phase III trial.

Textbooks 

Exercise Class Assignments 

Course Plan

We will learn statistical methods used in medicine, especially in epidemiology and clinical trials. Terminology specific to medical applications will be explained and some specialized methods will be covered. We will review study designs used in medical studies (cohort study, case-control study, randomized controlled trial) and explain how to analyze each of them. Ethical and administrative aspects of human experiments and their impact on handling statistical issues will be discussed.

Prerequisites

This course assumes advanced knowledge of statistical theory and practice, especially linear regression, logistic regression, loglinear models, survival analysis. Master students of "Probability, statistics and econometrics" must have completed the course on Linear Regression (NMSA407), Advanced Regression Models (NMST432), and Censored Data Analysis (NMST531) before enrolling in this course.